Acta Scientific PAEDIATRICS (ISSN: 2581-883X) Volume 4 Issue 4 April 2021 Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin Gianfranco Trapani 1 , Vassilios Fanos 2 , Giulia Maiocco 3 , Chiara Peila3*, Enrico Bertino 3 , Osama Al Jamal 4 , Michele Fiore 5 , Vincenzo Bembo 6 , Domenico Careddu 7 , Lando Barberio 8 , Luisella Zanino 9 and Giuseppe Verlato 10 1 Alfred Nobel’s Friends International Association Study Center and Primary Care Pediatrician, Sanremo, Italy 2 Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy 3 Neonatal Care Unit, Department of Public Health and Pediatric Sciences, Univer- sity of Turin, Turin, Italy 4 Alfred Nobel’s Friends international Association Study Center and Primary Care Pediatrician, Cagliari, Italy 5 Primary Care Pediatrician, Genoa, Italy 6 Primary Care Pediatrician, Frosinone, Italy 7 Alfred Nobel’s Friends International Association Study Center and Primary Care Pediatrician, Novara, Italy 8 Primary Care Pediatrician, Taggia, Italy 9 Alfred Nobel’s Friends International Association Study Center and Primary Care Pediatrician, Turin, Italy 10 Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Pub- lic Health, University of Verona, Verona, Italy *Corresponding Author: Chiara Peila, Neonatal Care Unit, Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy. Research Article Received: January 18, 2021 Published: March 09, 2021 © All rights are reserved by Chiara Peila., et al. Abstract Introduction: Symptoms of SARS-CoV-2 infection in children are nonspecific and shared with other common acute viral illnesses (fever, respiratory or gastrointestinal symptoms and cutaneous signs), thus making clinical differential diagnosis tricky. In Italy, first line management of pediatric care is handed over to Primary Care Pediatricians (PCPs), who were not allowed to directly perform diagnostic tests during the recent COVID-19 outbreak. Without a confirmatory diagnosis, PCPs could only collect information on “COVID-19 like symptoms” rather than identify typical COVID-19 symptoms. Aim: To evaluate the prevalence of COVID-19 like symptoms in outpatient children, during Italian lockdown. To provide PCPs a risk score to be used in clinical practice during the differential diagnosis process. Citation: Chiara Peila ., et al. “Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin". Acta Scientific Paediatrics 4.4 (2021): 03-11. Methods: A survey was submitted to 50 PCPs (assisting 47,500 children) from 7 different Italian regions between the 4 th of March and the 23 rd of May 2020 (total and partial lockdown period). COVID-19 like symptoms in the assisted children were recorded, as well as presence of confirmed/suspected cases in children’s families, which was taken as proxy of COVID-19. Multivariable logistic regression was accomplished to estimate the risk of having suspected/confirmed cases in families, considering symptoms as poten - tial determinants. Results: 2,300 children (4.8% of overall survey population) fell ill with COVID-19 like symptoms, 3.1% and 1.7% during total and partial lockdown period respectively. The concurrent presence of fatigue, cough, and diarrhea in children, in absence of sore throat/ earache and abnormal skin signs, represents the maximum risk level of having a suspected/confirmed case of COVID-19 at home. Conclusion: The percentage of children presenting COVID-19 like symptoms at home has been remarkable also during the total lock down period. The present study identified a pattern of symptoms which could help, in a cost-effective perspective, PCPs in daily clinical practice to define priorities in addressing children to the proper diagnostic procedure. Keywords: COVID-19 Like Symptoms; Risk Score; Primary Care Pediatrician; Lockdown Period; Pediatric Population; Nasopharyn- geal Swab Introduction Much information has been learned about the infection of SARS- CoV-2 and coronavirus disease (COVID-19), and much more has still to be learned, especially in children [1]. Indeed COVID-19 is rare in the pediatric population, both in China and in Europe [2-4]. In Italy cumulative incidence COVID-19 is as low as 0.42/1000 in the first decade of life and peaks to 24.6/1000 in people aged 90 years and over [5]. Moreover, COVID-19 in pediatric age is usually milder and with better prognosis than in adults and older people, likely due to both exposure and host factors [6,7] . This was confirmed world - wide and also in Italy [8] . Fatality rate is 0.2% in the first decade of life and becomes > 30% in people aged 80 years and over [5]. Sev- eral mechanisms have been proposed to explain the favorable pat - tern of COVID-19 in children. SARS-CoV-2 is able to penetrate cells thanks to the binding to angiotensin-converting enzyme 2 (ACE2), and then to downregulate it. ACE2 cleaves angiotensin 2 (with a pro-inflammation and pro-fibrosis role) to angiotensin (1-7) form (which is active in anti-inflammation pathway) [9]. In children, ACE2 binding domain may be immature and dysfunctional, thus preventing optimal infectious process, but at the same time ACE2 levels are higher and may provide higher concentration of angio- tensin (1-7) heptapeptide [10-12]. Furthermore, children show stronger innate immunity secondary to live-vaccines and high inci- dence of respiratory virus infections, whereas immune-senescence is found in elderly [10]. Finally, children may have had fewer risk contacts during the spread of the SARS-CoV-2 infection than adults and elderly people because of early closing of schools [13]. Infection in children may be asymptomatic or may occur with a pool of typical symptoms all over the world: acute upper respira- tory tract symptoms including fever, fatigue, myalgia, cough, sore throat, pharyngeal erythema, runny nose, earache and sneezing have been the first associated with mild SARS-COV-2 infection in pediatric age. Later digestive symptoms, such as nausea, vomiting, abdominal pain and diarrhea were observed in COVID-19 positive children. Cutaneous manifestations can be additionally found in confirmed cases. Moderate-to-severe infections are characterized by pneumonia, tachypnea, or tachycardia [14-18]. In our study, these typical COVID- 19 symptoms in absence of a firm diagnosis were defined as “COVID-19 like symptoms”. Since 1978 the Ital - ian National Health Service (NHS) has provided Pediatric Primary Care (PPC) to children through the use of Primary Care Pediatri- cians (PCPs), (Law 833/1978 and subsequent ones concerning the National Health Service) [19]. The organization of PPC in Italy is unique in Europe as even the first line management of children is handed over to the PCPs till the end of the developmental age. The task of Italian PCPs is to answer the psychosocial and devel- opmental needs of children, assisting families in promoting their children’s health and well-being [20]. Of note, the pediatric health- care global cost for the National Health fund is 0.2-0.3% of overall 04 Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin Citation: Chiara Peila ., et al. “Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin". Acta Scientific Paediatrics 4.4 (2021): 03-11. budget [21] . During this outbreak it was quite tricky when a family with a child with acute illness (fever, respiratory or gastrointestinal symptoms, and cutaneous signs) reach out PCP for a diagnosis: ac- cording to precautionary principles, European recommendation is to visit this child with all the necessary personal protective equip - ment (PPE) [22]. It must be underlined that PCPs in Italy were not allowed to directly perform the nasopharyngeal swab, and request for it to be performed by responsible healthcare personnel could be possible only if a confirmed case is found in the child family, or no clinical diagnosis was feasible. Aim of the Study Primary aim of our study was to find out whether outpatient children have developed COVID- 19 like symptoms during Italian lockdown and social distancing, and to explore the impact of CO - VID-19 like disorders on PPC system. Secondary aim was to pro- vide PCPs useful insights to be used in clinical practice during the difficult clinical differential diagnosis process in the COVID-19 era. Materials and Methods Study population From the 4 th of March to the 23 rd of May 2020, during the Ital- ian lockdown period, an online survey with anonymous question - naires was submitted to 50 PCPs, assisting 47,500 children aged 0 - 16 years, from 7 different Italian regions. COVID-19 like symptoms were identified in Literature as the most common in COVID-19 positive children [14,15,17,23,24] and defined as the presence of one of the following: fever, fatigue, rhinitis, sore throat or earache, cough, nausea or vomiting, diarrhea, or abnormal skin sign. PCPs completed the questionnaires for each child with COVID-19 like symptoms addressing their surgeries. During the first part of the outbreak a long latency was present between naso-pharyngeal swab request and results, thus swab results, if performed, were not collected in the survey. Baseline clinical data were collected in the questionnaires. The presence of confirmed or suspected cases in children’s families was recorded according to the WHO Global Sur - veillance for human infection with COVID-19 definitions [25]. Italian regions were classified as low, medium or high-risk areas based on the 26 th of May COVID-19 update, issued by the Italian Na- tional Institute of Health [26]. In detail, Calabria and Sardinia were low risk areas, Lazio medium risk area, Emilia-Romagna, Liguria, Lombardy and Piedmont high-risk areas. The observation period was divided in total lockdown, from the 4 th of March till the 3 rd of May, and partial lockdown, from the 4 th till the 23 rd of May. Statistical analyses Significance of the association between area of residence, gen - der, age class, symptoms and presence of suspected/confirmed cas - es in the family was evaluated by Fisher’s exact test. Multivariable analysis was accomplished by a logistic regression model, where suspected/confirmed cases in the family (0 = absent, 1 = present) was the response variable, and area of residence (0 = low/medium risk, 1 = high risk), gender, age (< 1, 1 - 5, 6 - 10, 11 - 16 years) and symptoms were the potential determinants. Results were reported as Odds Ratios (ORs), and p values were computed by the Wald test. Goodness-of-fit was evaluated by the Hosmer-Lemeshow test. Coefficients derived from logistic regression were used to estimate the risk of suspected/confirmed cases in specific subgroups. Prev - alence of symptoms in our study population was compared with the one reported by Parri., et al . considering a cohort of 100 Italian children assessed in 17 Pediatric Hospitals and positive to SARS- CoV-2 [27]. Results 2,300 children, representing the 4.8% (95% CI 4.7 - 5.0%) of our whole pediatric population, visited PCPs for COVID-19 like symptoms. 1,464 children were visited from the 4 th of March till the 3 rd of May, and 836 from the 4 th till the 23 rd of May, so that the average number of visits per working day was 35.7 during the total lockdown and 55.7 during the partial lockdown. Males (n = 1,242, 54.0%) were more prevalent than females (n = 1,058, 46%), and median age was 4 years (range 0 - 16 years). Age distribution significantly differed between the Italian hospital series recently published [27] and the PPC survey (present study), as the former mostly comprised children in the first year of life or adolescents aged 11 - 18 years, while the latter mostly recruited children aged 1 - 5 years (53.6%) or 6 - 10 years (26.1%) (Table 1). Comorbidities affected 27% of hospitalized children, while they were rare in the PPC series. On the contrary, fever, fatigue and skin abnormalities were more frequently reported in children visited in PPC than in the hospital (Table 1). As expected, the proportion of children living with suspected and confirmed cases was significantly greater in high than me - dium/low risk areas and during total than partial lockdown (p < 05 Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin Citation: Chiara Peila ., et al. “Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin". Acta Scientific Paediatrics 4.4 (2021): 03-11. Hospital series [27] (n = 100) Pediatric Primary Care survey (n = 2300) p value* Males (%) 57 (57%) 1242 (54.0%) 0.609 Age class (years) <0.001 <1 40 (40%) 153 (6.7%) 1-5 15 (15%) 1233 (53.6%) 6-10 21 (21%) 601 (26.1%) >10** 24 (24%) 313 (13.6%) Comorbidities 27 (27%) 55 (2.4%) < 0.001 Fever 54 (54) 1479 (64.3) 0.043 Cough 44 (44) 871 (37.9) 0.247 Rhinorrhea 22 (22) 571 (24.8) 0.556 Shortness of breath 11 (11) --- Drowsiness 11 (11) --- Nausea or vomiting 10 (10) 294 (12.8) 0.538 Diarrhea 9 (9) 380 (16.5) 0.051 Fatigue 9 (9) 472 (20.5) 0.003 Abnormal skin signs 3 (3) 283 (11.8) 0.004 Table 1: Symptoms of COVID-19 + children (prevalence) in a hospital series compared with symptoms of children attending PPC in Italy (modified from [27]). *: p values were computed by Fisher’s exact test. **: 10 - 18 years in the hospital series, 10 - 16 years in the PPC survey. 0.001). The risk of suspected/confirmed cases in the family was affected by neither gender nor the presence of comorbidities and increased with increasing age (Table 2). Children living in a family with confirmed COVID-19 cases had a higher prevalence of diarrhea and fatigue, and a lower prevalence of sore throat/earache and abnormal skin signs than children with no family cases. Accordingly, also the prevalence of nausea and vomiting tended to be the highest among children with confirmed cases, but the difference was not significant. Fever and cough were N No infection (n = 1892) Suspected (n = 225) Confirmed (n = 183) P value* Residence <0.001 Low risk area 927 868 ( 93.6 ) 53 (5.7) 6 (0.6) Medium risk area 153 145 ( 94.8 ) 3 (2.0) 5 (3.3) High risk area 1220 879 (72.0) 169 ( 13.9 ) 172 ( 14.1 ) Time of the survey <0.001 Total lockdown 1464 1141 (77.9) 181 ( 12.4 ) 142 ( 9.7 ) Partial lockdown 836 751 ( 89.8 ) 44 (5.3) 41 (4.9) Gender 0.113 Males 1242 1011 (81.4) 136 (11.0) 95 (7.6) Females 1058 881 (83.3) 89 (8.4) 88 (8.3) Age class (years) <0.001 < 1 153 139 ( 90.8 ) 8 (5.2) 6 (3.9) 1 - 5 1233 1062 ( 86.1 ) 100 (8.1) 71 (5.8) 6 - 10 601 475 (79.0) 65 ( 10.8 ) 61 ( 10.1 ) 11 - 16 313 216 (69.0) 52 ( 16.6 ) 45 ( 14.4 ) Comorbidi- ties 0.493 No 2245 1843 (97.4) 222 (98.7) 180 (98.4) Yes 55 49 (2.6) 3 (1.3) 3 (1.6) Table 2: COVID-19 infection in the children’s family as a function of gender, age, residence, time of the survey. Significance differences are highlighted in bold. more common among children living in a family with suspected COVID-19 cases. A possible explanation could be that fever and cough are more common in the early phase of COVID- 19 infection, while diarrhea and fatigue prevail later on (Table 3). In multivariable analysis, the risk to have suspected/confirmed cases at home was five-fold higher in high than low/medium risk areas, increased with increasing age, and was not affected by gen- der. Among symptoms, fatigue, cough and diarrhea were sugges- tive of family suspected/confirmed cases, while sore throat/ear - ache and abnormal skin symptoms were associated with no cases at home (Table 4). 06 Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin Citation: Chiara Peila ., et al. “Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin". Acta Scientific Paediatrics 4.4 (2021): 03-11. No infection (n = 1892) Suspected (n = 225) COVID-19 Positive (n = 183) P value* Fever 1,217 (64.3) 158 (70.2) 104 (56.8) 0.020 Fatigue 327 (17.3) 76 (33.8) 69 ( 37.7 ) <0.001 Rhinitis 471 (24.9) 57 (25.3) 43 (23.5) 0.908 Sore throat/ earache 694 (36.7) 56 (24.9) 38 (20.8) <0.001 Cough 667 (35.3) 128 (56.9) 76 (41.5) <0.001 Nausea or vomiting 236 (12.5) 27 (12.0) 31 (16.9) 0.215 Diarrhea 286 (15.1) 46 (20.4) 48 (26.2) <0.001 Abnormal skin signs 251 (13.3) 18 (8.0) 14 (7.7) 0.009 Table 3: Children with symptoms (percent) as a function of COVID-19 infection in the family. *P value was computed by the Fisher’s exact test. OR (95% CI) P value* Residence (high vs low risk area) 5.32 (4.00 - 7.08) <0.001 Gender (Females vs Males) 0.98 (0.77 - 1.24) 0.852 Age (years) < 1 1 (reference) 1 - 5 1.92 (1.06 - 3.49) 0.033 6 - 10 2.77 (1.50 - 5.14) 0.001 11 - 16 3.82 (2.02 - 7.21) <0.001 Symptoms (yes vs no) Fever 0.97 (0.75 - 1.26) 0.835 Fatigue 2.10 (1.60 - 2.74) <0.001 Rhinitis 0.96 (0.72 - 1.29) 0.799 Sore throat/earache 0.50 (0.38 - 0.67) <0.001 Cough 1.97 (1.51 - 2.56) <0.001 Nausea or vomiting 0.83 (0.57 - 1.20) 0.312 Diarrhea 1.68 (1.21 - 2.33) 0.002 Abnormal skin signs 0.56 (0.37 - 0.87) 0.009 Table 4: Risk factors for the presence of suspected/confirmed case(s) in the family *P values was computed by the Wald test. Odds Ratios (OR) and the corresponding 95% Confidence Interval (95% CI) was computed by a logistic regression model. The risk of living with a suspected/confirmed case was quanti - fied for high risk areas (Figure 1) and low/medium risk areas (Fig - ure 2) through the coefficients estimated by the logistic regression model. For instance, baseline risk of having a suspected/confirmed case in the family was about 30% in the children aged 6-10 years from high risk areas, it increased to about 40% in children with fatigue, or cough or diarrhea, to about 50% in the presence of 2 of these symptoms and peaked to 62.6% when the 3 symptoms were simultaneously present. On the contrary, this probability de- creased to about 20% in children with sore throat/earache or skin symptoms, and further to 14.3% in the presence of both symptoms. The corresponding figures were much lower for children aged 6 - 10 years living in low/medium risk areas. The baseline risk of having suspected/confirmed cases in the family was 8.1%, it in - creased to 11 - 13% in children with fatigue or cough or diarrhoea, to 16 - 18% in the presence of 2 of these symptoms and peaked to 24.6% when the 3 symptoms were simultaneously present. The risk became very low (5%) in children with sore throat/earache or abnormal skin symptoms, and even lower (3%) in the presence of both symptoms. 07 Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin Citation: Chiara Peila ., et al. “Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin". Acta Scientific Paediatrics 4.4 (2021): 03-11. Figure 1: Probability of having a suspected/confirmed case in the family as a function of symptoms, which were significant predictors in the multivariable logistic model. Estimates refer to children aged 1 - 5 years (upper panel), 6 - 10 years (middle panel), 11 - 16 years (lower panel) living in high risk areas. Columns are probabilities, bars are 95% confidence intervals. Sore throat = sore throat/earache. Figure 2: Probability of having a suspected/confirmed case in the family as a function of symptoms, which were significant predictors in the multivariable logistic model. Estimates refer to children aged 1 - 5 years (upper panel), 6 - 10 years (middle panel), 11 - 16 years (lower panel) living in low/medium risk areas. Columns are probabilities, bars are 95% confidence intervals. Sore throat = sore throat/earache Discussion This is the first survey held in Italy with the PCPs, addressing the pattern of pediatric surgeries access during the complete lock- down and for 20 days thereafter. Nowadays the actual number of COVID-19 cases in Italy is still unknown, and probably underesti- mated, especially in the pediatric population [5]. Of note the per- centage of children presenting COVID-19 like symptoms at home has been remarkable during the lockdown period (4.8%). This was unexpected, as children are less likely to get sick when the schools are closed. The proportion of children with suspected/confirmed cases in the family more than halved from the total to the partial lockdown period, reflecting the decrease in COVID19 incidence in Italy [5]. However, access to pediatric surgeries increased from the total to the partial lockdown period from 35.7 to 55.7 visits/ working day, and this probably reflects increased family mobility and persistent parents’ anxiety. The risk of having suspected/con - firmed cases at home was 5-fold larger in children living in high than low-medium risk areas and increased with increasing age, in agreement with Italian epidemiological data. Indeed, the cumula- tive incidence of COVID-19 by the 23 rd of June 2020 was 0.42/1000 in children in the first decade of life and increased to 0.67/1000 in 08 Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin Citation: Chiara Peila ., et al. “Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin". Acta Scientific Paediatrics 4.4 (2021): 03-11. the second decade. In the whole population cumulative incidence ranged from 0.60/1000 in Calabria to 9.25/1000 in Lombardy [5]. Interestingly, the prevalence of major COVID-like symptoms in Italy is intriguingly similar between the present study on children addressing pediatric surgeries, who did not perform any swab, and the study by Parri., et al . [27] on children admitted to the hospi- tal with positive swab. This similarity suggests that prevalence of COVID-19 could be actually underestimated in Italian outpatient children. Anyway, PCPs were not enabled to do the differential di- agnosis between COVID-19 and other disorders as they lack the necessary diagnostic tools. The main practical finding of our study is that the concurrent presence of fatigue, cough and diarrhea in children, in absence of sore throat/earache and abnormal skin signs, represents the maxi - mum risk level of having a suspected/confirmed case of COVID-19 at home, which was assumed as a proxy of COVID-19 in the pres - ent study. A dose-response association with symptoms having a suspected/confirmed case at home emerged, as the risk increased from children without fatigue, cough and diarrhea to children with only 1 symptom and further to children with 2 or 3 symptoms. On the other hand, a child who presents both sore throat/earache and cutaneous manifestations and no fatigue, cough, or diarrhea, was less likely to have a suspected/confirmed case at home, and hence to be infected with SARS-CoV-2. Given the importance to early identify COVID-19 positive outpa - tient children, our risk score could be a useful instrument in PCPs clinical practice to define priorities in addressing children to the proper diagnostic procedure, even if they have not affected famil- iars. As suggested by the Federal Office of Public Health (UFSP) of the Swiss Confederation [28], not all the outpatient children with mild COVID-19 like symptoms need to be tested for COVID-19, and the final decision is up to PCPs and parents. To our knowledge, this is the first survey held in Italy with the PCPs, addressing the pattern of pediatric surgeries access during the complete lockdown and for 20 days thereafter. Moreover, the survey considered 2,300 children from 7 Italian regions. The main limitation of this study was the lack of nasopharyngeal swab as a diagnostic tool for SARS-CoV-2 infection. Of note, this limitation was not peculiar of the present study but affected the entire pri- mary care setting in Italy, for both children and adults. To circum- vent this limitation the presence of suspected/confirmed case of COVID-19 at home was assumed as a proxy of COVID-19. Conclusion The percentage of children presenting COVID-19 like symptoms at home has been remarkable also during the total lockdown pe- riod. COVID-19 pandemic is not over and could outbreak again in autumn. Health care resources are limited, so it is not realistic to perform a nasopharyngeal swab in all symptomatic children. The present study identified a pattern of symptoms which could help, in a cost-effective perspective, PCPs in daily clinical practice, to define priorities in addressing children to the proper diagnostic procedure. Acknowledgements We warmly thank all the membership of the Research Collabo- rative Group of Primary Care Pediatricians: Giulia Franchi, Mari - sa Gramegna, Giorgio Lepre, Cosimo Claudio Muia, Mirella Nigro, Luisella Prete, Karim Primon, Emanuela Pilade, Maria Adele Zoia, Claudia Piasenti, Daniela Piana, Fabrizio Fraioli, Mario Moi, Cri- stina Perrera, Simonetta Serra, Tiziana Casti, Paolo Rosas, Miriam Concas, Pietro Maria De Giovanni, Pierangela Mussinu, Giuseppe Cera, Antonio Pala, Bruna Moi, Sabrina Pilia, Licia Mocci, Cosimo Lanza, Marcello Semprini, Antonella Lavagetto, Anna Timitilli, Ca- rola Malfatti, Roberto Bezzi, Livio Fattorini, Franca Passeri, Dona- to Orru, Cristian Noto, Paola Pescosolido, Patrizio Veronelli, Nadia Chiapello, Maria Grazia Giuliani, Norberto Porta, Giuseppe Squaz - zini, Lorenzo Parodi, Fulvia Gatto, Giovanna Levato, and Giulietta Manca. Conflict of Interest None to declare. Bibliography 1. 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Swiss Confed- eration (2020). • Prompt Acknowledgement after receiving the article • Thorough Double blinded peer review • Rapid Publication • Issue of Publication Certificate • High visibility of your Published work Assets from publication with us Website: www.actascientific.com/ Submit Article: www.actascientific.com/submission.php Email us: editor@actascientific.com Contact us: +91 9182824667 11 Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin Citation: Chiara Peila ., et al. “Children with COVID-19 Like Symptoms in Italian Paediatric Surgeries: The Dark Side of the Coin". Acta Scientific Paediatrics 4.4 (2021): 03-11.